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the reduction in hba 1c in patients treated with sitagliptin and insulin with or without metformin was -1.

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metformin is recommended to be temporarily discontinued before any radiographic study involving iodinated contrast agents, such as a contrast-enhanced ct scan or angiogram , as the contrast dye may temporarily impair kidney function, indirectly leading to lactic acidosis by causing retention of metformin in the body.

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figure 2 mean change from baseline for a1c over 52 weeks in a study comparing januvia to glipizide as add-on therapy in patients inadequately controlled on metformin per protocol population .

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